Recovery is not influenced by continuation of silver sulfadiazine therapy. Rebound to normal leukocyte levels follows onset within 2 to 3 days. Maximal white blood cell depression occurs within 2 to 4 days of initiation of therapy. 1,2,3 Leukopenia associated with silver sulfadiazine administration is primarily characterized by decreased neutrophil count. Several cases of transient leukopenia have been reported in patients receiving silver sulfadiazine therapy. The use of SILVADENE Cream 1% (silver sulfadiazine) in some cases of glucose-6-phosphate dehydrogenase-deficient individuals may be hazardous, as hemolysis may occur. However, the incidence of clinically reported fungal superinfection is low. If allergic reactions attributable to treatment with silver sulfadiazine occur, continuation of therapy must be weighed against the potential hazards of the particular allergic reaction.įungal proliferation in and below the eschar may occur. There is potential cross-sensitivity between silver sulfadiazine and other sulfonamides. Some of the reactions, which have been associated with sulfonamides, are as follows: blood dyscrasias including agranulocytosis, aplastic anemia, thrombocytopenia, leukopenia, and hemolytic anemia dermatologic and allergic reactions, including life-threatening cutaneous reactions gastrointestinal reactions hepatitis and hepatocellular necrosis CNS reactions and toxic nephrosis. Although few have been reported, it is possible that any adverse reaction associated with sulfonamides may occur. Silver sulfadiazine is not a carbonic anhydrase inhibitor and may be useful in situations where such agents are contraindicated.Ībsorption of silver sulfadiazine varies depending upon the percent of body surface area and the extent of the tissue damage. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach.Results of In Vitro Testing with SILVADENE ® Cream 1% (silver sulfadiazine) Concentration of Silver Sulfadiazine Number of Sensitive Strains/Total Number of Strains Tested Genus & Species It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. See the FDA's Safe Disposal of Medicines website ( ) for more information if you do not have access to a take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. Instead, the best way to dispose of your medication is through a medicine take-back program. However, you should not flush this medication down the toilet. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Keep this medication in the container it came in, tightly closed, and out of reach of children. Keep the burned area covered with cream at all times reapply the cream to any area that becomes uncovered. Cover the cleaned burned area with a 1/16-inch (0.2-centimeter) thickness of cream. Always wear a sterile, disposable glove when you apply silver sulfadiazine. If your burn becomes infected or if your infection worsens, call your doctor.īefore applying the medication, clean the burned area and remove any dead or burned skin. Gently wash the burned skin area daily to help remove dead skin. Your burn must be healed so that infection is no longer a problem. Do not use more or less of it or use it more often than prescribed by your doctor.ĭo not apply this drug to infants less than 2 months of age.ĭo not stop using silver sulfadiazine until your doctor tells you to do so. Use silver sulfadiazine exactly as directed. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Silver sulfadiazine usually is applied once or twice a day.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |